The Laboratory of Muscle Stem Cells and Gene Regulation (LMSCGR) at the NIAMS of the NIH has a postdoctoral position available for an individual with a background in molecular technology and cell culture methodology. Within the Lab, our group is focused on the translational research aimed at understanding the molecular and biochemical mechanisms of skeletal muscle damage in Pompe disease, also known as a lysosomal glycogen storage disorder. Pompe disease is a rare and fatal muscle disorder caused by a deficiency of the enzyme acid alpha-glucosidase. In particular, we are interested in the role of autophagy in the pathogenesis of the disease with the goal to improve the currently available enzyme replacement therapy. The fellow will use previously generated Pompe mouse models with alterations in autophagic genes, and will be responsible for the generation of novel transgenic models.
Requirements:
Applicants must have an M.D. or a Ph.D degree with expertise in molecular biology, and a previous track record of successful research. A good command of English is required.
A wide variety of state-of-the-art research facilities are available either within the laboratory or elsewhere on the NIH campus.
To Apply:
Please submit your CV, bibliography, statement of research interests, and the names of three references to: Vittorio Sartorelli, M.D., Laboratory of Muscle Stem Cell and Gene Regulation, NIAMS, NIH; 50 South Drive, Room 1351, Bethesda, MD 20892; E-mail: sartorev@mail.nih.gov
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